从 2,4-二硝基氯苯诱导的小鼠皮肤损伤中分离的 Gracillin 的抗变态反应特性。
Anti-Atopic Properties of Gracillin Isolated from on 2,4-Dinitrochlorobenzene-Induced Skin Lesions in Mice.
机构信息
College of Pharmacy, Pusan National University, Busan 46241, Korea.
Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung 25451, Korea.
出版信息
Nutrients. 2018 Sep 1;10(9):1205. doi: 10.3390/nu10091205.
Naturally occurring saponins have been reported to have anti-inflammatory and immunomodulatory effects. However, the effects of gracillin, a main saponin component of (), on atopic dermatitis (AD), have not been previously studied. The aim of this study was to determine whether gracillin isolated from has an anti-AD effect on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions in SKH-1 hairless mice. Topical co-treatment of gracillin and DNCB for two weeks markedly reduced symptoms typical of AD (redness, itching, swelling and skin lichenification), decreased transepidermal water loss (TEWL) and increased skin hydration. In addition, gracillin strongly inhibited PI-induced IL-4 expression in RBL-2H3 cells and in the skins of AD mice. Our results suggest gracillin is a potential candidate for the prevention and treatment of AD and other inflammatory skin disorders.
天然存在的皂苷已被报道具有抗炎和免疫调节作用。然而，（）的主要皂苷成分之一 gracillin 对特应性皮炎（AD）的影响尚未被研究过。本研究旨在确定 gracillin 从（）中分离出来是否对 SKH-1 无毛小鼠的 2,4-二硝基氯苯（DNCB）诱导的 AD 样皮肤损伤具有抗 AD 作用。 gracillin 与 DNCB 联合局部治疗两周可显著减轻 AD 的典型症状（发红、瘙痒、肿胀和皮肤苔藓化），减少经表皮水分流失（TEWL）并增加皮肤水分。此外，gracillin 强烈抑制 RBL-2H3 细胞和 AD 小鼠皮肤中 PI 诱导的 IL-4 表达。我们的结果表明 gracillin 是预防和治疗 AD 及其他炎症性皮肤疾病的潜在候选药物。
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