细菌中群体感应对抗菌药物耐药性的调控
Quorum-Sensing Regulation of Antimicrobial Resistance in Bacteria.
作者信息
Zhao Xihong, Yu Zixuan, Ding Tian
机构信息
Research Center for Environmental Ecology and Engineering, Key Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory of Novel Reactor and Green Chemistry Technology, School of Environmental Ecology and Biological Engineering, Wuhan Institute of Technology, Wuhan 430205, China.
College of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou 310058, China.
出版信息
Microorganisms. 2020 Mar 17;8(3):425. doi: 10.3390/microorganisms8030425.
Quorum sensing is a cell-to-cell communication system that exists widely in the microbiome and is related to cell density. The high-density colony population can generate a sufficient number of small molecule signals, activate a variety of downstream cellular processes including virulence and drug resistance mechanisms, tolerate antibiotics, and harm the host. This article gives a general introduction to the current research status of microbial quorum-sensing systems, focuses on the role of quorum-sensing systems in regulating microbial resistance mechanisms, such as drug efflux pump and microbial biofilm formation regulation, and discusses a new strategy for the treatment of drug-resistant bacteria proposed by using quorum quenching to prevent microbial resistance.
群体感应是一种广泛存在于微生物群落中的细胞间通信系统，与细胞密度相关。高密度的菌落群体能够产生足够数量的小分子信号，激活包括毒力和耐药机制在内的多种下游细胞过程，耐受抗生素，并对宿主造成损害。本文对微生物群体感应系统的当前研究现状进行了概述，重点关注群体感应系统在调节微生物耐药机制中的作用，如药物外排泵和微生物生物膜形成调控，并探讨了利用群体淬灭预防微生物耐药性从而治疗耐药菌的新策略。
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