LuxS/AI-2 系统的调控机制与细菌耐药性
Regulatory Mechanisms of the LuxS/AI-2 System and Bacterial Resistance.
机构信息
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China
Key Laboratory of Molecular Pathogen and Immunology of Animal of Luoyang, Luoyang, China.
出版信息
Antimicrob Agents Chemother. 2019 Sep 23;63(10). doi: 10.1128/AAC.01186-19. Print 2019 Oct.
Abstract
The quorum-sensing (QS) system is an intercellular cell-cell communication mechanism that controls the expression of genes involved in a variety of cellular processes and that plays critical roles in the adaption and survival of bacteria in their environment. The LuxS/AI-2 QS system, which uses AI-2 (autoinducer-2) as a signal molecule, has been identified in both Gram-negative and Gram-positive bacteria. As one of the important global regulatory networks in bacteria, it responds to fluctuations in the numbers of bacteria and regulates the expression of a number of genes, thus affecting cell behavior. We summarize here the known relationships between the LuxS/AI-2 system and drug resistance, discuss the inhibition of LuxS/AI-2 system as an approach to prevent bacterial resistance, and present new strategies for the treatment of drug-resistant pathogens.
摘要
群体感应 (QS) 系统是一种细胞间的细胞通讯机制，控制着与多种细胞过程相关的基因的表达，在细菌适应和生存其环境中起着关键作用。LuxS/AI-2 QS 系统使用 AI-2（自诱导物-2）作为信号分子，已在革兰氏阴性菌和革兰氏阳性菌中被鉴定。作为细菌中重要的全球调控网络之一，它响应细菌数量的波动并调节许多基因的表达，从而影响细胞行为。在这里，我们总结了已知的 LuxS/AI-2 系统与耐药性之间的关系，讨论了抑制 LuxS/AI-2 系统作为预防细菌耐药性的一种方法，并提出了治疗耐药性病原体的新策略。
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