外泌体来源的 miR-let-7c 通过在骨髓微环境中极化 M2 巨噬细胞促进多发性骨髓瘤血管生成。
Exosome-derived miR-let-7c promotes angiogenesis in multiple myeloma by polarizing M2 macrophages in the bone marrow microenvironment.
机构信息
School of Basic Medical Sciences, Zhengzhou University, No. 100 Ke Xue Avenue, Zhengzhou, 450000, China; Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, No. 1 Jian She Dong Avenue, Zhengzhou, 450000, China; Henan Key Laboratory of Tumor Pathology, Zhengzhou University, No. 40 Da Xue Avenue, Zhengzhou, 450000, China.
Department of Pathology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jian She Dong Avenue, Zhengzhou, 450000, China.
出版信息
Leuk Res. 2021 Jun;105:106566. doi: 10.1016/j.leukres.2021.106566. Epub 2021 Mar 31.
Angiogenesis is an integral part of the multiple myeloma (MM) microenvironment, and affects tumorigenesis, progression, invasion, and metastasis. Exosomes are essential for cell-cell communication and help in regulating the bone marrow microenvironment. Herein, we investigated macrophage polarization and angiogenesis in MM in vitro via exosome-derived miR-let-7c. We observed that exosomal miR-let-7c secreted by mesenchymal stem cells promoted M2 macrophage polarization, thereby enhancing angiogenesis in the bone marrow microenvironment. Suppressing miR-let-7c expression significantly inhibited vascular endothelial cell function in myeloma. Thus, exosomal miR-let-7c may be a reliable biomarker for early prediction of tumor progression and a promising therapeutic target for MM.
血管生成是多发性骨髓瘤（MM）微环境的一个组成部分，影响肿瘤发生、进展、侵袭和转移。外泌体是细胞间通讯的关键，有助于调节骨髓微环境。在此，我们通过外泌体来源的 miR-let-7c 研究了 MM 中的巨噬细胞极化和血管生成。我们观察到，间充质干细胞分泌的外泌体 miR-let-7c 促进 M2 巨噬细胞极化，从而增强骨髓微环境中的血管生成。抑制 miR-let-7c 的表达显著抑制骨髓瘤中的血管内皮细胞功能。因此，外泌体 miR-let-7c 可能是肿瘤进展早期预测的可靠生物标志物，也是 MM 的有前途的治疗靶点。
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