网络药理学，揭示中药方剂药理学机制的一种有前途的方法。
Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula.
机构信息
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China; Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Key Laboratory of Ministry of Education of Theory and Therapy of Muscles and Bones, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China; Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Key Laboratory of Ministry of Education of Theory and Therapy of Muscles and Bones, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
出版信息
J Ethnopharmacol. 2023 Jun 12;309:116306. doi: 10.1016/j.jep.2023.116306. Epub 2023 Feb 27.
ETHNOPHARMACOLOGICAL RELEVANCE
Network pharmacology is a new discipline based on systems biology theory, biological system network analysis, and multi-target drug molecule design specific signal node selection. The mechanism of action of TCM formula has the characteristics of multiple targets and levels. The mechanism is similar to the integrity, systematization and comprehensiveness of network pharmacology, so network pharmacology is suitable for the study of the pharmacological mechanism of Chinese medicine compounds.
AIM OF THE STUDY
The paper summarizes the present application status and existing problems of network pharmacology in the field of Chinese medicine formula, and formulates the research ideas, up-to-date key technology and application method and strategy of network pharmacology. Its purpose is to provide guidance and reference for using network pharmacology to reveal the modern scientific connotation of Chinese medicine.
MATERIALS AND METHODS
Literatures in this review were searched in PubMed, China National Knowledge Infrastructure (CNKI), Web of Science, ScienceDirect and Google Scholar using the keywords "traditional Chinese medicine", "Chinese herb medicine" and "network pharmacology". The literature cited in this review dates from 2002 to 2022.
RESULTS
Using network pharmacology methods to predict the basis and mechanism of pharmacodynamic substances of traditional Chinese medicines has become a trend.
CONCLUSION
Network pharmacology is a promising approach to reveal the pharmacology mechanism of Chinese medicine formula.
民族药理学相关性：网络药理学是基于系统生物学理论、生物系统网络分析和多靶点药物分子设计特定信号节点选择的新学科。中药方剂的作用机制具有多靶点、多层次的特点。其机制类似于网络药理学的整体性、系统性和综合性，因此网络药理学适用于中药化合物的药理机制研究。
研究目的：本文总结了网络药理学在中药方剂领域的应用现状及存在问题，制定了网络药理学的研究思路、最新关键技术及应用方法和策略。旨在为运用网络药理学揭示中药的现代科学内涵提供指导和参考。
材料与方法：本文通过关键词“traditional Chinese medicine”“Chinese herb medicine”和“network pharmacology”，在 PubMed、中国知网（CNKI）、Web of Science、ScienceDirect 和 Google Scholar 中检索文献，综述的文献时间跨度为 2002 年至 2022 年。
结果：利用网络药理学方法预测中药药效物质的基础和机制已成为一种趋势。
结论：网络药理学是揭示中药方剂药理学机制的一种很有前途的方法。
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