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个性化营养:通过基因洞察定制饮食建议。

Personalized Nutrition: Tailoring Dietary Recommendations through Genetic Insights.

机构信息

Department of Health, Nutrition, and Food Sciences, College of Education, Health, and Human Sciences, Florida State University, Tallahassee, FL 32306, USA.

Department of Kinesiology and Nutrition Sciences, School of Integrated Health Sciences, University of Nevada, Las Vegas, NV 89154, USA.

出版信息

Nutrients. 2024 Aug 13;16(16):2673. doi: 10.3390/nu16162673.

Abstract

Personalized nutrition (PN) represents a transformative approach in dietary science, where individual genetic profiles guide tailored dietary recommendations, thereby optimizing health outcomes and managing chronic diseases more effectively. This review synthesizes key aspects of PN, emphasizing the genetic basis of dietary responses, contemporary research, and practical applications. We explore how individual genetic differences influence dietary metabolisms, thus underscoring the importance of nutrigenomics in developing personalized dietary guidelines. Current research in PN highlights significant gene-diet interactions that affect various conditions, including obesity and diabetes, suggesting that dietary interventions could be more precise and beneficial if they are customized to genetic profiles. Moreover, we discuss practical implementations of PN, including technological advancements in genetic testing that enable real-time dietary customization. Looking forward, this review identifies the robust integration of bioinformatics and genomics as critical for advancing PN. We advocate for multidisciplinary research to overcome current challenges, such as data privacy and ethical concerns associated with genetic testing. The future of PN lies in broader adoption across health and wellness sectors, promising significant advancements in public health and personalized medicine.

摘要

个性化营养(PN)代表了饮食科学的一种变革性方法,其中个体的基因谱指导量身定制的饮食建议,从而更有效地优化健康结果和管理慢性疾病。这篇综述综合了 PN 的关键方面,强调了饮食反应的遗传基础、当代研究和实际应用。我们探讨了个体遗传差异如何影响饮食代谢,从而强调了营养基因组学在制定个性化饮食指南中的重要性。PN 的当前研究强调了影响各种情况(包括肥胖和糖尿病)的重要基因-饮食相互作用,这表明如果根据遗传谱进行定制,饮食干预可能更加精确和有益。此外,我们讨论了 PN 的实际实施,包括基因测试技术的进步,使实时饮食定制成为可能。展望未来,本综述确定了生物信息学和基因组学的强大整合对于推进 PN 至关重要。我们提倡开展多学科研究,以克服与基因测试相关的数据隐私和伦理问题等当前挑战。PN 的未来在于在健康和保健领域更广泛地采用,有望在公共卫生和个性化医学方面取得重大进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2514/11357412/742842256942/nutrients-16-02673-g001.jpg

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