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过量铁摄入对婴儿生长的影响及荧光和比色检测方法:综述

Impacts of Excessive Iron Intake on Infant Growth and Fluorimetric and Colorimetric Detection Methods: A Comprehensive Review.

作者信息

Shafie Alaa, Ashour Amal Adnan, Tayeb Faris J, Felemban Mohammed Fareed

机构信息

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O.Box 11099, Taif, 21944, Saudi Arabia.

Department of Oral & Maxillofacial Surgery and Diagnostic Sciences, Faculty of Dentistry, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.

出版信息

J Fluoresc. 2025 Feb 13. doi: 10.1007/s10895-025-04183-4.

Abstract

Iron is an essential nutrient involved in various physiological processes, including oxygen transport, enzyme activity, and cellular metabolism. However, excessive iron accumulation in the body can disrupt this delicate balance, leading to adverse effects on growth and development. Maintaining optimal iron levels is crucial for pediatric health, as both deficiency and overload pose significant risks. Fluorometric and colorimetric sensing techniques play a vital role in accurately detecting Fe/Fe levels in biological matrices, facilitating early diagnosis and intervention in cases of iron overload. This study explores the impact of excess iron on children growth parameters, offering insights that can inform public health policies and clinical strategies for promoting healthy development. Additionally, this review highlights recent advancements (2022-2024) in organic colorimetric and fluorometric probes, which exhibit high sensitivity and selectivity for Fe/Fe detection at trace levels.

摘要

铁是一种必需营养素,参与各种生理过程,包括氧气运输、酶活性和细胞代谢。然而,体内铁的过度积累会破坏这种微妙的平衡,对生长发育产生不利影响。维持最佳铁水平对儿童健康至关重要,因为铁缺乏和铁过载都会带来重大风险。荧光和比色传感技术在准确检测生物基质中的铁/亚铁水平方面发挥着至关重要的作用,有助于对铁过载病例进行早期诊断和干预。本研究探讨了过量铁对儿童生长参数的影响,提供了可为促进健康发育的公共卫生政策和临床策略提供参考的见解。此外,本综述重点介绍了有机比色和荧光探针的最新进展(2022 - 2024年),这些探针在痕量水平下对铁/亚铁检测具有高灵敏度和选择性。

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