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非编码RNA与氧化应激在癌症进展中的相互作用。

The crosstalk between non-coding RNAs and oxidative stress in cancer progression.

作者信息

Sun Qiqi, Lei Xiaoyong, Yang Xiaoyan

机构信息

School of Pharmaceutical Science, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China.

出版信息

Genes Dis. 2024 Apr 10;12(3):101286. doi: 10.1016/j.gendis.2024.101286. eCollection 2025 May.

Abstract

As living standards elevate, cancers are appearing in growing numbers among younger individuals globally and these risks escalate with advancing years. One of the reasons is that instability in the cancer genome reduces the effectiveness of conventional drug treatments and chemotherapy, compared with more targeted therapies. Previous research has discovered non-coding RNAs' crucial role in shaping genetic networks involved in cancer cell growth and invasion through their influence on messenger RNA production or protein binding. Additionally, the interaction between non-coding RNAs and oxidative stress, a crucial process in cancer advancement, cannot be overlooked. Essentially, oxidative stress results from the negative effects of radicals within the body and ties directly to cancer gene expression and signaling. Therefore, this review focuses on the mechanism between non-coding RNAs and oxidative stress in cancer progression, which is conducive to finding new cancer treatment strategies.

摘要

随着生活水平的提高,全球范围内癌症在年轻人群体中的发病率日益增加,且这些风险会随着年龄的增长而上升。原因之一是,与更具针对性的疗法相比,癌症基因组的不稳定性降低了传统药物治疗和化疗的效果。先前的研究已经发现,非编码RNA通过影响信使RNA的产生或蛋白质结合,在塑造参与癌细胞生长和侵袭的基因网络中发挥着关键作用。此外,非编码RNA与氧化应激(癌症进展中的一个关键过程)之间的相互作用也不容忽视。本质上,氧化应激是由体内自由基的负面影响导致的,并且与癌症基因表达和信号传导直接相关。因此,本综述聚焦于癌症进展过程中非编码RNA与氧化应激之间的机制,这有助于找到新的癌症治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d468/11870203/46aef7e3a81b/gr1.jpg

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