身体活动与DNA甲基化预测的表观遗传时钟之间的关系。

Relationship between physical activity and DNA methylation-predicted epigenetic clocks.

作者信息

You Yanwei, Chen Yuquan, Ding Hao, Liu Qiyu, Wang Rui, Xu Kailin, Wang Qingyuan, Gasevic Danijela, Ma Xindong

机构信息

Division of Sports Science & Physical Education, Tsinghua University, Beijing, 100084, China.

IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing, 100084, China.

出版信息

NPJ Aging. 2025 Apr 12;11(1):27. doi: 10.1038/s41514-025-00217-0.

DOI:10.1038/s41514-025-00217-0

PMID:40221397

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11993638/

Abstract

This study investigates the relationship between physical activity (PA) levels and DNA methylation (DNAm)-predicted epigenetic clocks in a U.S. population sample (n = 948, mean age 62, 49% female). Eight epigenetic clocks were analyzed, revealing that higher PA levels were significantly associated with younger biological ages across all indicators, with the strongest effects observed for SkinBloodAge and LinAge. Multivariable linear regression models, adjusted for sociodemographic and lifestyle factors, highlighted the potential of PA to reduce biological ageing. Subgroup analyses indicated that these associations were more pronounced among non-Hispanic whites, individuals with a BMI of 25-30, and former smokers, suggesting that the impact of PA varies across different groups. These findings emphasize the role of PA in slowing biological ageing and reducing age-related health risks. Promoting regular PA, especially among older adults and those with higher BMI, could improve well-being and lifespan, highlighting PA as a modifiable factor in healthy ageing and age-related disease prevention.

摘要

本研究在美国人群样本（n = 948，平均年龄62岁，49%为女性）中调查了身体活动（PA）水平与DNA甲基化（DNAm）预测的表观遗传时钟之间的关系。分析了八个表观遗传时钟，结果显示，在所有指标中，较高的PA水平均与较年轻的生物学年龄显著相关，其中皮肤血液年龄（SkinBloodAge）和林氏年龄（LinAge）的影响最为显著。经社会人口学和生活方式因素调整的多变量线性回归模型突出了PA在减少生物学衰老方面的潜力。亚组分析表明，这些关联在非西班牙裔白人、BMI为25至30的个体以及曾经吸烟者中更为明显，这表明PA的影响因不同群体而异。这些发现强调了PA在减缓生物学衰老和降低与年龄相关的健康风险方面的作用。推广定期进行PA，尤其是在老年人和BMI较高的人群中，可以改善幸福感和寿命，突出了PA作为健康衰老和预防与年龄相关疾病的一个可改变因素的重要性。