Molnupiravir for treatment of adults with mild or moderate COVID-19: a systematic review and meta-analysis of randomized controlled trials.

BACKGROUND

The effects of molnupiravir in treating patients with non-severe COVID-19 remain uncertain.

OBJECTIVES

To evaluate the efficacy and safety of molnupiravir in adult patients with mild or moderate COVID-19.

DATA SOURCES

PubMed, Embase, CENTRAL, Web of Science, and WHO COVID-19 database up to 27 December 2022.

STUDY ELIGIBILITY CRITERIA

Randomized controlled trials with no language restrictions.

PARTICIPANTS

Adults with mild or moderate COVID-19.

INTERVENTIONS

Molnupiravir against standard care or placebo.

ASSESSMENT OF RISK OF BIAS

We used a revision of RoB-2 criteria.

METHODS OF DATA SYNTHESIS

Outcomes were mortality, hospital admission, viral clearance, time to viral clearance, time to symptom resolution or clinical improvement, any adverse events, and serious adverse events. We performed DerSimonian-Laird random-effects meta-analyses to summarize the evidence and evaluated the certainty of evidence using the Grading of Recommendations Assessment, Development, and Evaluation approach.

RESULTS

Nine randomized controlled trials enrolling 30 472 patients proved eligible. Majority of patients were outpatients, with a mean age ranging from 35 to 56.6 years. In adult patients with mild or moderate COVID-19, molnupiravir probably reduces mortality (relative risk [RR], 0.43; 95% CI, 0.20-0.94; risk difference [RD], 0.1% fewer; moderate certainty) and the risk of hospital admission (RR, 0.67; 95% CI, 0.45-0.99; RD, 1.4% fewer; moderate certainty) and may reduce time to viral clearance (mean difference, -1.81 days; 95% CI, -3.31 to -0.31; low certainty) and time to symptom resolution or clinical improvement (mean difference, -2.39 days; 95% CI, -3.71 to -1.07; low certainty). Molnupiravir probably increases the rate of viral clearance (RR, 3.47; 95% CI, 2.43-4.96; RD 16.1% more; moderate certainty) at 7 days (±3 days) and likely does not increase serious adverse events (RR, 0.84; 95% CI, 0.61-1.15; RD 0.1% fewer; moderate certainty).

CONCLUSIONS

In adult patients with mild or moderate COVID-19, molnupiravir likely reduces mortality and risk of hospital admission probably without increasing serious adverse events.