英国生物银行474,074名参与者白细胞端粒长度的测量与初步特征分析
Measurement and initial characterization of leukocyte telomere length in 474,074 participants in UK Biobank.
作者信息
Codd V, Denniff M, Swinfield C, Warner S C, Papakonstantinou M, Sheth S, Nanus D E, Budgeon C A, Musicha C, Bountziouka V, Wang Q, Bramley R, Allara E, Kaptoge S, Stoma S, Jiang T, Butterworth A S, Wood A M, Di Angelantonio E, Thompson J R, Danesh J N, Nelson C P, Samani N J
机构信息
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
出版信息
Nat Aging. 2022 Feb;2(2):170-179. doi: 10.1038/s43587-021-00166-9. Epub 2022 Feb 17.
Leukocyte telomere length (LTL) is a proposed marker of biological age. Here we report the measurement and initial characterization of LTL in 474,074 participants in UK Biobank. We confirm that older age and male sex associate with shorter LTL, with women on average ~7 years younger in 'biological age' than men. Compared to white Europeans, LTL is markedly longer in African and Chinese ancestries. Older paternal age at birth is associated with longer individual LTL. Higher white cell count is associated with shorter LTL, but proportions of white cell subtypes show weaker associations. Age, ethnicity, sex and white cell count explain ~5.5% of LTL variance. Using paired samples from 1,351 participants taken ~5 years apart, we estimate the within-individual variability in LTL and provide a correction factor for this. This resource provides opportunities to investigate determinants and biomedical consequences of variation in LTL.
白细胞端粒长度（LTL）是一种被提议作为生物学年龄的标志物。在此，我们报告了英国生物银行中474,074名参与者的LTL测量及初步特征。我们证实，年龄较大和男性与较短的LTL相关，女性的“生物学年龄”平均比男性小约7岁。与欧洲白人相比，非洲和中国血统人群的LTL明显更长。父亲生育时年龄较大与个体LTL较长相关。白细胞计数较高与较短的LTL相关，但白细胞亚型比例的相关性较弱。年龄、种族、性别和白细胞计数解释了LTL变异的约5.5%。利用来自1351名参与者、间隔约5年采集的配对样本，我们估计了LTL的个体内变异性并为此提供了一个校正因子。该资源为研究LTL变异的决定因素和生物医学后果提供了机会。
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