抗菌肽SET-M33L和SET-M33L-PEG是对抗包括多重耐药菌株在内的强生物膜形成的有前景的药物。
Antimicrobial Peptides SET-M33L and SET-M33L-PEG Are Promising Agents Against Strong Biofilm-Forming , Including Multidrug-Resistant Isolates.
作者信息
Fontanot Alessio, Croughs Peter D, Cortese Clelia, de Bruijn Adrianus C J M, Falciani Chiara, Pini Alessandro, Ellinger Isabella, Unger Wendy W J, Hays John P
机构信息
Laboratory of Pediatrics, Department of Pediatrics, Sophia Children's Hospital, Erasmus University Medical Center (Erasmus MC), 3015 GD Rotterdam, The Netherlands.
Department of Medical Microbiology & Infectious Diseases, Erasmus University Medical Center (Erasmus MC), 3015 GD Rotterdam, The Netherlands.
出版信息
Antibiotics (Basel). 2025 Jul 11;14(7):699. doi: 10.3390/antibiotics14070699.
: The antimicrobial peptides (AMPs) SET-M33L and SET-M33L-PEG were investigated against 10 clinical isolates of . : Their minimum inhibitory concentrations (MICs), minimum bactericidal concentrations (MBCs), and minimum biofilm inhibitory concentrations (MBICs) were evaluated against tobramycin, ceftazidime, and polymyxin B. : MICs and MBCs were 7- to 100-fold lower than tobramycin, and 10- to 300-fold lower than ceftazidime. Fractional inhibitory concentration (FIC) indices showed an additive effect, while fractional bactericidal concentration (FBC) indices showed synergistic effects (FBC < 0.5) for most isolates. : SET-M33L and SET-M33L-PEG are promising antimicrobial agents against strong biofilm-forming , including MDR isolates.
研究了抗菌肽SET-M33L和SET-M33L-PEG对10株临床分离菌的抗菌活性。评估了它们对妥布霉素、头孢他啶和多粘菌素B的最低抑菌浓度（MIC）、最低杀菌浓度（MBC）和最低生物膜抑制浓度（MBIC）。SET-M33L和SET-M33L-PEG的MIC和MBC比妥布霉素低7至100倍，比头孢他啶低10至300倍。部分抑菌浓度（FIC）指数显示为相加作用，而部分杀菌浓度（FBC）指数对大多数分离菌显示为协同作用（FBC<0.5）。SET-M33L和SET-M33L-PEG是有前景的抗生物膜形成菌的抗菌剂，包括多重耐药分离菌。
Zotero 插件