MEME 套件。
The MEME Suite.
作者信息
Bailey Timothy L, Johnson James, Grant Charles E, Noble William S
机构信息
Institute for Molecular Bioscience, The University of Queensland, Brisbane 4072, Queensland, Australia
Institute for Molecular Bioscience, The University of Queensland, Brisbane 4072, Queensland, Australia.
出版信息
Nucleic Acids Res. 2015 Jul 1;43(W1):W39-49. doi: 10.1093/nar/gkv416. Epub 2015 May 7.
The MEME Suite is a powerful, integrated set of web-based tools for studying sequence motifs in proteins, DNA and RNA. Such motifs encode many biological functions, and their detection and characterization is important in the study of molecular interactions in the cell, including the regulation of gene expression. Since the previous description of the MEME Suite in the 2009 Nucleic Acids Research Web Server Issue, we have added six new tools. Here we describe the capabilities of all the tools within the suite, give advice on their best use and provide several case studies to illustrate how to combine the results of various MEME Suite tools for successful motif-based analyses. The MEME Suite is freely available for academic use at http://meme-suite.org, and source code is also available for download and local installation.
MEME套件是一套功能强大的基于网络的集成工具，用于研究蛋白质、DNA和RNA中的序列基序。这些基序编码许多生物学功能，对它们的检测和表征在细胞分子相互作用研究中很重要，包括基因表达的调控。自2009年《核酸研究》网络服务器专刊上对MEME套件进行上一次描述以来，我们又添加了六个新工具。在此，我们描述了该套件中所有工具的功能，给出了最佳使用建议，并提供了几个案例研究，以说明如何结合各种MEME套件工具的结果进行基于基序的成功分析。MEME套件可在http://meme-suite.org上免费供学术使用，其源代码也可供下载和本地安装。
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