肽基脯氨酰顺反异构酶 Pin1 在疾病发病机制中的作用。
Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis.
机构信息
The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan, China.
School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, China.
出版信息
Theranostics. 2021 Jan 19;11(7):3348-3358. doi: 10.7150/thno.45889. eCollection 2021.
Pin1 belongs to the peptidyl-prolyl cis-trans isomerases (PPIases) superfamily and catalyzes the cis-trans conversion of proline in target substrates to modulate diverse cellular functions including cell cycle progression, cell motility, and apoptosis. Dysregulation of Pin1 has wide-ranging influences on the fate of cells; therefore, it is closely related to the occurrence and development of various diseases. This review summarizes the current knowledge of Pin1 in disease pathogenesis.
Pin1 属于肽基脯氨酰顺反异构酶（PPIase）超家族，能够催化靶底物中脯氨酸的顺反转换，从而调节多种细胞功能，包括细胞周期进程、细胞迁移和细胞凋亡。Pin1 的失调对细胞命运有广泛的影响；因此，它与各种疾病的发生和发展密切相关。本综述总结了 Pin1 在疾病发病机制中的最新知识。
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