唾液与唾液诊断在口腔健康促进中的作用。
Role of Saliva and Salivary Diagnostics in the Advancement of Oral Health.
机构信息
1 Department of Oral Biology, Dental College, University of Manitoba, Winnipeg, MB, Canada.
2 Center for Oral/Head and Neck Oncology Research, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, CA, USA.
出版信息
J Dent Res. 2019 Feb;98(2):133-141. doi: 10.1177/0022034518816961.
Abstract
The objective of this article was to provide an account of some of the developments related to saliva over the first 100 years of the Journal of Dental Research and to outline some of the many biomarkers identified in saliva in the last few years. The first section covers findings in salivary physiology, biochemistry, calcium phosphate chemistry related to saliva, microbiology, and the role of saliva in maintaining oral health. The second section highlights salivary diagnostics, salivaomics, and saliva exosomics in the context of the emerging theme of personalized and precision medicine.
摘要
本文旨在介绍《牙研究杂志》创刊 100 年来与唾液相关的一些进展，并概述近年来在唾液中发现的许多生物标志物。第一部分涵盖了唾液生理学、生物化学、与唾液相关的钙磷化学、微生物学以及唾液在维持口腔健康中的作用等方面的发现。第二部分重点介绍了唾液诊断学、唾液组学和唾液外泌体组学，以及个性化和精准医学这一新兴主题的背景。
相似文献
1
Role of Saliva and Salivary Diagnostics in the Advancement of Oral Health.
J Dent Res. 2019 Feb;98(2):133-141. doi: 10.1177/0022034518816961.
2
The emerging landscape of salivary diagnostics.
Periodontol 2000. 2016 Feb;70(1):38-52. doi: 10.1111/prd.12099.
3
Scientific frontiers: emerging technologies for salivary diagnostics.
Adv Dent Res. 2011 Oct;23(4):360-8. doi: 10.1177/0022034511420433.
4
Salivaomics.
J Am Dent Assoc. 2012 Oct;143(10 Suppl):19S-24S. doi: 10.14219/jada.archive.2012.0339.
5
Saliva diagnostics: Salivaomics, saliva exosomics, and saliva liquid biopsy.
J Am Dent Assoc. 2023 Aug;154(8):696-704. doi: 10.1016/j.adaj.2023.05.006.
6
Oral-based diagnostics. Festschrift to honor Irwin Mandel and proceedings of a conference. October 10-12, 2006. Lake Lanier Islands, Georgia, USA.
Ann N Y Acad Sci. 2007 Mar;1098:xiii, 1-515. doi: 10.1196/annals.1384.045.
7
Saliva, diagnostics, and dentistry.
Adv Dent Res. 2011 Oct;23(4):353-9. doi: 10.1177/0022034511420432.
8
Saliva-Exosomics in Cancer: Molecular Characterization of Cancer-Derived Exosomes in Saliva.
Enzymes. 2017;42:125-151. doi: 10.1016/bs.enz.2017.08.002. Epub 2017 Oct 9.
9
Salivary biomarkers--an update.
Dent Update. 2012 Oct;39(8):566-8, 571-2. doi: 10.12968/denu.2012.39.8.566.
10
Salivary diagnostics.
Oper Dent. 2012 Nov-Dec;37(6):562-70. doi: 10.2341/12-143-BL. Epub 2012 Jul 12.
引用本文的文献
1
Management of Dental Demineralization in a Patient with Complex Medical Conditions: A Case Report and Clinical Outcomes.
Reports (MDPI). 2025 Mar 27;8(2):39. doi: 10.3390/reports8020039.
2
Comparative study of the profile of supragingival dental plaque and tooth decay in patients with lupus erythematosus and rheumatoid arthritis.
BMC Oral Health. 2025 Mar 18;25(1):399. doi: 10.1186/s12903-025-05762-4.
3
Levilactobacillus brevis CD2 as a multifaceted probiotic to preserve oral health: results of a double-blind, randomized, placebo-controlled trial in healthy adults.
J Transl Med. 2025 Jan 28;23(1):128. doi: 10.1186/s12967-024-06000-1.
4
Biomimetic Effect of Saliva on Human Tooth Enamel: A Scanning Electron Microscopic Study.
Int J Dent. 2025 Jan 4;2025:1664620. doi: 10.1155/ijod/1664620. eCollection 2025.
5
Oral Hygiene, Dietary Habits, and Saliva Properties in Relation to the Decayed, Missing, and Filled Teeth Index of Dental Students: A Pilot Study.
Medicina (Kaunas). 2024 Dec 8;60(12):2023. doi: 10.3390/medicina60122023.
6
Pathogenic mechanisms and potential applications of extracellular vesicles from periodontal pathogens in periodontitis.
Front Immunol. 2024 Dec 20;15:1513983. doi: 10.3389/fimmu.2024.1513983. eCollection 2024.
7
Population Proteomics: A Tool to Gain Insights Into the Inflamed Periodontium.
Proteomics. 2025 Jan;25(1-2):e202400055. doi: 10.1002/pmic.202400055. Epub 2024 Dec 30.
8
Dynamics of the oral microbiome during orthodontic treatment and antimicrobial advances for orthodontic appliances.
iScience. 2024 Nov 22;27(12):111458. doi: 10.1016/j.isci.2024.111458. eCollection 2024 Dec 20.
9
Immunoaffinity-enriched salivary small extracellular vesicles in periodontitis.
Extracell Vesicles Circ Nucl Acids. 2023 Dec 30;4(4):698-712. doi: 10.20517/evcna.2023.48. eCollection 2023.
10
Design strategy of hydrogel wound dressings based on oral special environment.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2024 Dec 1;42(6):689-698. doi: 10.7518/hxkq.2024.2024262.
本文引用的文献
1
Are the mutans streptococci still considered relevant to understanding the microbial etiology of dental caries?
BMC Oral Health. 2018 Jul 31;18(1):129. doi: 10.1186/s12903-018-0595-2.
2
Salivary secretion in health and disease.
J Oral Rehabil. 2018 Sep;45(9):730-746. doi: 10.1111/joor.12664. Epub 2018 Jun 25.
3
A Mathematical Model Supports a Key Role for Ae4 (Slc4a9) in Salivary Gland Secretion.
Bull Math Biol. 2018 Feb;80(2):255-282. doi: 10.1007/s11538-017-0370-6. Epub 2017 Dec 5.
4
Novel approaches for bioinformatic analysis of salivary RNA sequencing data for development.
Bioinformatics. 2018 Jan 1;34(1):1-8. doi: 10.1093/bioinformatics/btx504.
5
Role of microbial biofilms in the maintenance of oral health and in the development of dental caries and periodontal diseases. Consensus report of group 1 of the Joint EFP/ORCA workshop on the boundaries between caries and periodontal disease.
J Clin Periodontol. 2017 Mar;44 Suppl 18:S5-S11. doi: 10.1111/jcpe.12682.
6
The oral microbiome - an update for oral healthcare professionals.
Br Dent J. 2016 Nov 18;221(10):657-666. doi: 10.1038/sj.bdj.2016.865.
7
A Guide to Medications Inducing Salivary Gland Dysfunction, Xerostomia, and Subjective Sialorrhea: A Systematic Review Sponsored by the World Workshop on Oral Medicine VI.
Drugs R D. 2017 Mar;17(1):1-28. doi: 10.1007/s40268-016-0153-9.
8
Evaluation of a novel saliva-based epidermal growth factor receptor mutation detection for lung cancer: A pilot study.
Thorac Cancer. 2016 Jul;7(4):428-36. doi: 10.1111/1759-7714.12350. Epub 2016 May 13.
9
Liquid Biopsy in Lung Cancer: A Perspective From Members of the Pulmonary Pathology Society.
Arch Pathol Lab Med. 2016 Aug;140(8):825-9. doi: 10.5858/arpa.2016-0163-SA. Epub 2016 May 19.
10
Circulating Tumor Cells and Circulating Tumor DNA: Challenges and Opportunities on the Path to Clinical Utility.
Clin Cancer Res. 2015 Nov 1;21(21):4786-800. doi: 10.1158/1078-0432.CCR-14-1190.
Zotero 插件